Being the broke-ass mental case I am, I go to a state-funded mental health clinic that doesn't prescribe any controlled substances...even benzos or other Schedule IV's. So you can imagine my surprise when my psych doctor brought up ketamine nasal spray at our last visit. She asked if I'd ever heard of it, to which I (maybe too enthusiastically) replied "Yes! You mean esketamine, right? I'd be open to trying that."
I'm considered treatment-resistant when it comes to depression and anxiety. I've tried every class of drugs except MAOIs & the old school antipsychotics like Thorazine--neither of which I'm interested in due to the health risks. I've happily accepted every prescription she's written for me, which I feel has contributed to her willingness to let me explore more "experimental" options like ketamine. Plus, the list of meds I've tried over the years is exceedingly long--in excess of 22 different drugs, many of which were very unpleasant or caused dangerous reactions. To qualify for esketamine, you only have to have failed TWO depression meds.
|Spray away the blues with Spravato!|
From my own research, plain racemic ketamine (generic) can also be administered intravenously or prescribed in the form of a nasal spray or lozenge and made by a compounding pharmacy for much cheaper. That would be ideal since it could be taken home in the latter 2 scenarios & would be much more affordable. Spravato seems to be a ripoff in that it's no more beneficial than ketamine but far more expensive. It may be 20 years before I'm able to try it, but it's still something to be hopeful about.
Do you have any personal experience with using ketamine--either prescribed or "off-label"--for depression? I'd love to hear your thoughts in the comments!